The Unsolved Case of the Oakland County Child Killer

The Oakland County Child Killer (OCCK) is an unknown responsible for the unsolved murders of four or more children, two girls and two boys, in Oakland County, Michigan, in 1976 and 1977. The Murders From February 1976 to March 1977, in Oakland County, Michigan, four children were kidnapped, held for up to 19 days, and then murdered. The killer would then dress them in their freshly pressed clothing, and leave their bodies carefully positioned on blankets of snow or laying in full sight next to a road. The murders resulted in the largest murder investigation in U.S. history at that time, but it failed to produce a suspect. Mark Stebbins In the afternoon on Sunday, February 15, 1976, 12-year-old Mark Stebbins of Ferndale, Michigan,  disappeared after  leaving  the American Legion Hall to go home to watch television. Four days later, on February 19, his body was found around 12 miles from his home, laying in a snowbank in a parking lot in Southfield. He was dressed in the same clothes that he had was wearing on the day that he was abducted, but they were cleaned and pressed. An autopsy determined that he had been with an object and strangled to death. Rope burns were discovered on his wrists, indicating that his hands had been tightly bound. Jill Robinson In the late afternoon of Wednesday, December 22, 1976, 12-year-old Jill Robinson of Royal Oak, got into an argument with her mother and decided to pack a bag and run away from home. It was the last day that she was seen alive. The next day, on December 23, her bicycle was discovered behind a store located on Main Street in Royal Oak. Three days after, her body was found lying on the side of Interstate 75 near Troy within full sight of the Troy police station. An autopsy determined that Jill had died from a shotgun blast to her face. Like Mark Stebbins, she was fully clothed in the clothing that she had worn when she disappeared. Placed next to her body, police found her backpack which was intact. Like Mark, her body appeared to be carefully placed on a pile of snow. Kristine Mihelich On Sunday, January 2, 1977, at around 3 p.m., 10-year-old Kristine Mihelich of Berkley, went to the nearby 7-Eleven and bought some magazines. She was never to be seen alive again. Her body was discovered 19 days later by a mail carrier who was on his rural route. Kristine was fully dressed and her body positioned in the snow. The killer had also closed Kristines eyes and folded her arms across her chest. Although her body was left along a rural road in Franklin Village, it was left in full view of several homes. An autopsy later revealed that she had been smothered. The Task Force Following Kristine Mihelich’s murder, authorities announced that they believed that the children had been murdered by stalking the area. An official task force was formed specifically to investigate the murders. It was made up of law enforcement from 13 communities and led by the Michigan State Police. Timothy King On Wednesday, March 16, 1977, at around 8 p.m., 11-year-old Timothy King left his Birmingham home with $0.30 cents to buy candy, his skateboard tucked under his arm. He was headed to a drugstore near his house in Birmingham. After making his purchase, he left the store through the back exit which led to a parking lot where he seemed to disappear into thin air. With yet another case of an  abducted and likely murdered child on their hands, the authorities decided to perform a massive search throughout the entire Detroit area. Television news stations and Detroit newspapers heavily reported about Timothy and the other murdered children. Timothy Kings father appeared on television, pleading with the kidnapper to not hurt his son and to let him go. Marion King, Timothys mother, wrote a letter that said she hoped she would see Timothy soon so that she could give him his favorite meal, Kentucky Fried Chicken. The letter was printed in â€Å"The Detroit News.† On the night of March 22, 1977, Timothy Kings body was found in a ditch alongside a road in Livonia. He was fully clothed, but it was obvious that his clothes had been cleaned and pressed. His skateboard had been placed next to his body. An autopsy report showed that Timothy had been sexually assaulted with an object and smothered to death. It was also revealed that he had eaten chicken before he was murdered. Before Timothy Kings body was found, a woman came forward with information about the missing boy. She told the task force that on the same night that boy went missing, she saw him talking to an older man in the parking lot behind the drugstore. She described Timothy and his skateboard. Not only had she seen Timothy, but she also got a pretty good look at the man he was talking to, as well as his car. She told the authorities that the man was driving a blue AMC Gremlin with white stripes on the side. With her help, a police sketch artist was able to do a composite drawing of the older man and of the car he was driving. The sketch was released to the public. Profile of the Killer The task force developed a profile of the based on descriptions given by witnesses who saw Timothy talking to a man on the night that he was abducted. The profile described a white male, dark complected, age 25 to 35, with shaggy hair and long sideburns. Because the person seemed to be able to gain the trust of children, the task force believed that the killer was possibly a police officer, doctor, or a clergyman. The profile went on to describe the killer as someone who was familiar with the area and probably lived alone, possibly in a remote area, since he was able to for several days without friends, family or neighbors knowing. The Investigation Over 18,000 tips came into the task force, and all of them were investigated. Although there were other crimes that the police discovered while doing their investigations, the task force had not gotten any closer to capturing the killer.   Allen and Frank Detroit psychiatrist Dr. Bruce Danto  and a member of the task force team received a letter a few weeks after Timothy King was murdered. The letter was written by someone who called themselves Allen. and claimed to be the of his roommate Frank who was the Oakland County Child Killer. In the letter, Allen described himself as guilt-ridden, remorseful, scared, suicidal, and on the brink of losing his mind. He said that he had been with Allen on many road trips looking for boys, but that he was never present when Frank abducted the children or when he murdered them Allen also wrote that Frank drove a Gremlin, but that he had junked it in Ohio, never to be seen again. To offer investigators a motive for the murders, Allen said that Frank killed children while fighting in Viet Nam and was traumatized by it. He was taking revenge on rich people so that they would suffer like he did while in Viet Nam. Allen wanted to work out a deal and offered to turn over incriminating pictures that could be used as evidence against Frank. In exchange, he wanted the Governor of Michigan to sign an agreement that would give him immunity  from prosecution. Dr. Danto agreed to meet Allen at a bar, but Allen did not show up and he was never heard from again. In December 1978 the decision was made to discontinue the task force and the state police took over the investigation.

Essay On Living The Dream - 1807 Words

Living the Dream: An Analysis on Why We Dream and Freud’s Early Work Living the Dream: An Analysis on Why We Dream and Freud’s Early Work It happens every night, whether you remember it or not and they can affect us long after we experience them. They are dreams and they continue to remain one of the biggest mysteries of the human mind. Psychologists have tried to comprehend why we dream and what our dreams mean but have yet to discover the truth behind them. Psychologists have also tried to make sense of our dreams and unconscious minds but none have been quite as successful as Freud and his theories on psychoanalysis, the different aspects of the unconscious mind (id, superego, and ego), wish fulfillment, etc. It is through the work†¦show more content†¦However, this theory only goes as far as explaining why we experience nightmares, not why we dream of normal or extraordinary things (Turner, Why Do We Dream? Modern Theories of Dreaming). One of Freudâ€℠¢s most popular dream theories is that on wish-fulfillment.What this means is that we dream of things we would like to happen or want to be real. Freud developed this theory after working with a particularly difficult patient, Irma. Freud was worried about her because her treatment was not going as well as he wanted and he was feeling guilty. One night he dreamed that he had met Irma at a party and examined her, he then saw a formula for a drug given to her by another doctor and realized her condition was the result of an unsterile syringe, thus, relieving him of his guilt (McLeod, Sigmund Freud). This is an example of wish-fulfillment because he had wished Irma’s condition was not his fault and his dream fulfilled this wish by allowing him to blame someone else. â€Å"Freud distinguished between the manifest content of a dream (what the dreamer remembers) and the latent content, the symbolic meaning of the dream (i.e. the underlying wish). The manifest content is often base d on the events of the day. The process whereby the underlying wish is translated into the manifest content is called dream-work. The purpose of dream-work is to transform the forbidden wish into a non-threatening form, thus reducing anxiety and allowing us to continuing sleeping.† (McLeod, SigmundShow MoreRelatedEssay about Living or Dying with the American Dream1274 Words   |  6 Pagesto be successful. We all dream of having a decent job, a house, a car or two, good social connections and the respect of our peers. We dream of opportunity and freedom. In Death of a Salesman by Arthur Miller, many characters are pursuing their own version of this dream, but they go about it in many different ways. Some see work and perseverance as necessities. Others think personal charm and popularity are essential in obtaining their dreams. We see the American Dream through the eyes of manyRead MoreEssay on The Corruption of the American Dream in The Great Gatsby1302 Words   |  6 Pa geseveryone longs for. This theme is better known as the American dream.The Great Gatsby is representative of the American dream in multiple ways. There are some aspects of the novel that symbolize the overall corruption of the American dream; there are others that signify the love of wealth, and the division of rich and poor. What exactly is the American dream? The American dream can be described as an idea, a concept, and a way of life. It can even be described as a form of ignorance. According toRead MoreLeave the Past Behind Essay examples1511 Words   |  7 Pagesstart to shake hand, make business or lifting embargoes which last decades. In the essay, â€Å"Vietnamese Youths No Longer Look Homeward† which was written by Nancy Wride focuses and reflects on young Vietnamese immigrations’ perspectives about the past and present. The essay is persuasive and realistic because there are so many interviews of the author with young American Vietnamese. The purpose of Wride in writing this essay is giving facts of the changes in American Vietnamese along with the change ofRead MoreImmigration Is Up Of The United States1274 Words   |  6 PagesFlora Ho Prof. Rocklin Hist 152 Essay Assignment Question 1 Immigration makes up of the United States. The life of an immigrant faces many struggles. Coming to the United States is a very difficult time for immigrant, especially when English is not their first language. In Oscar Handlin’s essay, Uprooted and Trapped: The One-Way Route to Modernity and Mark Wyman’s Coming and Going: Round Trip to America, both these essays describes the life of immigrants living in America and how they are ableRead MoreAnalysis Of The American Dream1063 Words   |  5 Pagesis the American Dream? Is it home ownership, gaining fame or wealth, having a great family or is it gaining a peace of mind? Many people have different versions of what the American Dream is, some people believe the dream is lost, and some people are right in the middle and still believe the American Dream is still alive. â€Å"The American Dream† by Brandon King debates about what the true state is left in the American Dream now. Throughout the essay, King asks if th e American Dream is dead, alive, onRead MoreThe American Dream By The Declaration Of Independence886 Words   |  4 PagesThe American Dream Introduction The American dream is the hope in freedom which enables all citizens to achieve their goals through hard work. The American dream is a belief of equality and prosperity in America. The American dream is a set of ideals that allows society to have high standards of living through hard work of citizens. The country has no barriers and every member who works hard has an equal opportunity. The hope of having a sense of social equality is the American dream (Stalp). It isRead MoreThe Great Gatsby : The American Dream927 Words   |  4 Pages2017 The Poor Man’s Dream Many believe that America is the land of riches, where anyone can become rich and wealthy. This idea is known as the American Dream, a set of ideals in which freedom includes the opportunity for a successful living. However, this ethos is completely false, and is nothing more than exactly that - a dream. Throughout the award-winning work of F. Scott Fitzgerald, â€Å"The Great Gatsby†, he gathers criticism about the American Dream. He denounces the dream by shedding the lightRead MoreThe Dream Of A Dream Story1426 Words   |  6 Pagesimagined. Within this essay, Friedman describes Bret’s journey of navigating the difficulties of life after his accident. The dream that can be analyzed in this essay is the idea of being useful in life and towards society; Friedman describes Bret’s process in achieving this dream through the inclusion of characters’ thoughts and actions. This narrative technique reveals the idea that dreams are not always singular, the peo ple surrounding you can play a crucial role in your dream story, and factorsRead MoreThe American Dream Is Still Alive Essay1610 Words   |  7 PagesThe American Dream Nowadays, many Americans wonder if the American Dream is still alive. At one point in our country, people felt that they could achieve success by working hard. However, after the economic hardships and recession of the 21st century, a number of Americans not only lost income, but some also lost their jobs. Although there has been slow progression to improve the economy, there are those who question whether or not the dream of Americans can ever be achieved again. With unemploymentRead MoreThe American Dream : Dead, Alive, Or On Hold By Brandon King953 Words   |  4 PagesThe American Dream The American Dream is one of those terms that people refer to when talking about immigration, financial status, and so much more. But what does the term really refer to? People used to think of the American Dream as financial prosperity, religious and financial freedom, and all around success. Now, the term may mean something similar, but people are much less focused on it. If anything, the American Dream today is focused on gaining material goods and proving your bank account

Singing in the Rain Free Essays

Singing in The Rain Brianna Walsh The Use of Singing and Dance in Singin’ In the Rain Singin’ In the Rain is a fantastic movie that shows the transition between silent films and â€Å"talkies. † This film, however, would have no impact what so ever if it were not a musical. The dancing in the movie gave it something different making the movie a classic, while the singing gave the premise of the movie. We will write a custom essay sample on Singing in the Rain or any similar topic only for you Order Now Lina Lamont would be the first problem with a normal film. If the movie did not have singing, the impact of how bad her voice really was would not be heard. The shocking shrill of her voice is really the premise of the whole movie. To really be appreciated, Lina waited a little before talking in the movie creating anticipation in the viewers. Her lack of dancing abilities just furthered her distance from the â€Å"talkies† and made the audience root against her. Kathy Selden really shined in this movie because of the singing and dancing. Her voice was fantastic and her dancing, especially paired with Don Lockwood, was better than many audiences had ever seen before. Without these two aspects in place, Kathy would not have been as likeable and her position as the underdog would have affected how the audience viewed her. Don Lockwood swooned all the ladies in this film with his charming singing and amazing tap dancing. He was really the star, in my eyes, of both of the categories. He was impossible to look away from because of his complicated choreography with his co-stars. Don would be nothing in this film if not for the singing and dancing. His part in the film would lessen immensely and he wouldn’t have made such an impact with the viewers. This film is a classic in American history solely because of the singing and dancing scenes. If these two things were not included in the film, it would have been lost among other movies of the time. How to cite Singing in the Rain, Essay examples

Global Entrepreneurship Cooler Jacket

Question: Discuss about theGlobal Entrepreneurship for Cooler Jacket. Answer: The Innovative Product: The proposed product is a Cooler Jacket. The jacket will have coolant material like ethylene glycol that will give a cool feeling to the one wearing it. Similar kind of jackets are available for the soldiers of some countries like India where the soldiers to perform their duty under high temperature (Shirish et al. 2016). These jackets provide a little relief to them. However, no such outfits are available for others. Therefore, such an innovative product designed for both men and women could be a good and innovative product in the market of Taiwan. Reason of Developing the Product: Taiwan has tropical climate where the summers are dry and warm. In winter as well, the temperature does not fall much (Lin et al. 2014). Both men and women of the region are fashionable and have affinity towards trendy clothes and accessories (Wu et al. 2015). Therefore, a product that will serve both the purpose of relief from scorching heat of the climate and as a trendy outfit shall have great acceptability among the people. Way of Developing the Product: The jackets can be manufactured at the home country and then they could be transported to Taiwan. The jackets could be supplied in the malls and shops where garments and accessories of various brands are available. On the other hand, a manufacturing unit can also be opened in Taiwan where the jackets could be manufactured and supplied to different stores. This will also reduce the manufacturing cost by certain percentage (Froud et al. 2014). References: Froud, J., Johal, S., Leaver, A. and Williams, K., 2014. Financialization across the Pacific: Manufacturing cost ratios, supply chains and power.Critical Perspectives on Accounting,25(1), pp.46-57. Lin, C.Y., Chua, Y.J., Hsu, H.H., Cheng, C.T. and Lin, Y.Y., 2014, May. Altitudinal and latitudinal dependence of future warming in an island of multi climate zones: Taiwan as an example. InEGU General Assembly Conference Abstracts(Vol. 16, p. 1442). Shirish, A., Kapadia, V., Kumar, S., Kumar, S., Mishra, S. and Singh, G., 2016. Effectiveness of a cooling jacket with reference to physiological responses in iron foundry workers.International journal of occupational safety and ergonomics, pp.1-7. Wu, M.S.S., Chaney, I., Chen, C.H.S., Nguyen, B. and Melewar, T.C., 2015. Luxury fashion brands: factors influencing young female consumers luxury fashion purchasing in Taiwan.Qualitative Market Research: An International Journal,18(3), pp.298-319.

Equitable doctrine of promissory estoppel

Introduction Under the equitable doctrine of promissory estoppels, promises that are made in bad faith in an agreement can be prosecuted in the court of law. Specifically, promissory estoppel allows other parties in the agreement to seek justice when the initial promises made were done in bad faith. Thus, this reflective treatise attempts to explicitly explain how the equitable doctrine of promissory estoppel is unjustifiable.Advertising We will write a custom essay sample on Equitable doctrine of promissory estoppel specifically for you for only $16.05 $11/page Learn More Why the equitable doctrine of Promissory Estoppel is Unjustifiable In the famous ruling in the case Waltons Stores (interstate) Ltd v Maher, the verdict gave the applicant a relief based on the defendant’s promise in the business contract. Reflectively, â€Å"the essence of the principle is that it requires a defendant to make fair and just compensation derived at the expense o f a claimant† (Doctrine of Promissory Estoppel 2012). This is brought out in the case of Pavey Mathews Pty Ltd v Paul. The principle can form the basis for which a claimant can seek relief. However, action based upon unjust enrichment is not based on the contract but independent of it (Turner 2005). As opined by Turner (2005), â€Å"restrictive covenants may, if certain conditions are satisfied, run with the land and bind purchasers of it to observe the covenants for the benefits of adjoining owners† (Tuner 2005, p. 43). An example is the Tulk v Moxhay 1848. In this particular case, the claimant had a listing of several real estate properties in Leicester square which he sold to the defendant based on an unwritten promise of safety standard guarantee. The defendant Elms pledged as a good will to the claimant, he would ensure that the railings and the gardens of the said properties would be maintained in their present condition and he will allow individuals tenants to t ill the gardens. The fact of the agreement was that the defendant had a prior knowledge of restrictions stipulated in the agreement with the claimant. Unfortunately, the defendant did not honor the said agreement made in form of a promise. The â€Å"defendant announced that he was going to build on the land, and the claimant; who still owned several adjacent houses, sought an injunction to restrain him from doing so from the court. It was held that the covenant would be enforced in equity against all subsequent purchasers with notice† (Doctrine of Promissory Estoppel 2012, par. 15). State laws expressly grant exceptions. This is though the various acts. For example, the Insurance Contract Act 1985, Bills of Exchange Act 1909, Cheques Act 1986, and Motor vehicle (Third party Insurance) Act 1942. For instance, â€Å"under the law of insurance, the exception to the principle of equitable doctrine of promissory estoppel has been applied to insurance policies are effected for the benefit of an upset party.Advertising Looking for essay on common law? Let's see if we can help you! Get your first paper with 15% OFF Learn More Where a policy of insurance is affected by the assured for his own life, and the policy is expressed to be for the benefit of his wife† (Doctrine of Promissory Estoppel 2012, par. 15). However, she cannot sue the insurance company on the policy unless it is assigned in writing or a trust has been declared by assured (Stone 2008). Therefore, a stranger to the contact cannot sue even if the contract is avowedly made for his benefit. Thus, â€Å"a stranger to the consideration cannot enforce an action on the promise made between two persons unless has in some way intervened in the agreement† (Doctrine of Promissory Estoppel 2012, par. 17). In the case, the person making the claims was due to get married to G’s daughter. The two parties allegedly made a written agreement in form of a promise note. The parties to the contract agreed to pay the claimant some money. Upon failing to honor the agreement, G was sued by the claimant. Though the sole object of the contract was to secure benefit to the claimant, he was not allowed to sue (Doctrine of Promissory Estoppel 2012). This is because the contract existed with the father and not with him. Besides, businesses often get into informal agreements with other businesses. The aim of these agreements is to facilitate smooth flow of work. Transactions resulting from such agreements need to be recorded in the books accounts in accordance with the accounting principle despite being informal. Therefore, an extension of liability ruling will frustrate informal agreements that determine success of the formal business contracts (Keenan Riches 2002). Aiders and abettors are parties to an offense. They share crime intent with the person who commits the crime. They may be liable as a principal, an accessory before or after the fact. Aiders and accomplice s are liable for fraudulent misrepresentation when they execute some overt act, or give advice or encouragement to commit a crime. The claimant bears the burden of proof. He must prove that there is a material misstatement or deceptive conduct, wrongful state of mind, a connection with the purchase or sale of a security, reliance, economic loss, and loss causation. Unfortunately, the equitable doctrine of promissory estoppels is silent on the fate aiders and abettors in a contract. This implies that when a trader has material information that is not known to the other party and he carries out trade with it, then the gains from the trade are unfair prima facie. However, there is no blanket court rule that declares trading with material insider information as illegal. The court handles cases arising from unfair trade in isolation. Therefore, it emerges that trading with material nonpublic information is unethical but may not be essentially against the law (August 2008).Advertising We will write a custom essay sample on Equitable doctrine of promissory estoppel specifically for you for only $16.05 $11/page Learn More From the above reflection, it is apparent that the equitable doctrine of promissory estoppels may not be justifiable in the face of ethics in business contracts. References August, R. (2008). International Business Law: Text Cases and Readings. New York: Routledge. Keenan, D, Riches, S. (2002). Business Law. New York: Pearson/Longman. Doctrine of Promissory Estoppel. (2012). Web. Stone, R. (2008). The Modern Law of Contract. New York: Routledge. Turner, C. (2005). The Comprehensive Guide to all the facts Contract Law. Hodder: Oxon. This essay on Equitable doctrine of promissory estoppel was written and submitted by user Carolina Mullins to help you with your own studies. You are free to use it for research and reference purposes in order to write your own paper; however, you must cite it accordingly. You can donate your paper here.

Free Essays on Automobile Pollution

I. Introduction In the past century, the automobile has come a far way from Henry Ford’s Model T. In the United States there has always been a high demand for cars, and with that demand comes the need for speed, and a need to have the best. And that is what major automobile industries have been giving our society because they know that they can profit greatly from it. These industries know what sells and they take advantage of it. In order to improve automobiles so that they meet these needs of our society, automobile industries turn to technology. Technology is what has turned the Ford Model T into a Ford Mustang 5.0. Of course with this technology comes flaws. The biggest and most obvious flaw is pollution. Because of pollution, we find ourselves asking the question of whether this technology has helped our society more than it has hurt it. And now that we have identified the problem, how can it be fixed, and how will fixing the problem of automobile pollution affect society also? II. Economic/Social Issue Pollution is becoming a big problem in today’s world. We are wrecking the earth day by day and automobiles are a very big part of that. As SUV’s get more and more popular, the pollution just increases. This world has become a very selfish place and people think only about themselves. They don't care that we are ruining the earth and soon enough, this world will not be livable. But as long as the earth is fine for right now, no one really cares. We like to put the blame on the business’ saying that it is their fault, but they make what we will buy. As long as the demand for SUV’s are so high, none of these car companies are gonna put much interest into the hybrid vehicles. It is up to the consumers to embrace this environmentally friendly way of living. Once the consumers allow change to take place, and put the value of life over their own possessions, we will be able to make the certain steps in cleaning ... Free Essays on Automobile Pollution Free Essays on Automobile Pollution I. Introduction In the past century, the automobile has come a far way from Henry Ford’s Model T. In the United States there has always been a high demand for cars, and with that demand comes the need for speed, and a need to have the best. And that is what major automobile industries have been giving our society because they know that they can profit greatly from it. These industries know what sells and they take advantage of it. In order to improve automobiles so that they meet these needs of our society, automobile industries turn to technology. Technology is what has turned the Ford Model T into a Ford Mustang 5.0. Of course with this technology comes flaws. The biggest and most obvious flaw is pollution. Because of pollution, we find ourselves asking the question of whether this technology has helped our society more than it has hurt it. And now that we have identified the problem, how can it be fixed, and how will fixing the problem of automobile pollution affect society also? II. Economic/Social Issue Pollution is becoming a big problem in today’s world. We are wrecking the earth day by day and automobiles are a very big part of that. As SUV’s get more and more popular, the pollution just increases. This world has become a very selfish place and people think only about themselves. They don't care that we are ruining the earth and soon enough, this world will not be livable. But as long as the earth is fine for right now, no one really cares. We like to put the blame on the business’ saying that it is their fault, but they make what we will buy. As long as the demand for SUV’s are so high, none of these car companies are gonna put much interest into the hybrid vehicles. It is up to the consumers to embrace this environmentally friendly way of living. Once the consumers allow change to take place, and put the value of life over their own possessions, we will be able to make the certain steps in cleaning ...

American Airlines Flight 1420 Research Paper Example | Topics and Well Written Essays - 1000 words

American Airlines Flight 1420 - Research Paper Example , underscore several key human factor failures and investigate how each of them generated some other failures by that creating a chain of errors that finally materialized to the accident. We shall address safety recommendations that would prove useful in the air travel industry. The findings regarding the accident of the McDonnell Douglas DC-9-82 (MD-82), N215AA reveal a situation that featured 2 flight crew members. It involved four flight attendants and 139 passengers (Aircraft accident report, 2001). The death toll hit 11, a tally that featured the captain and ten passengers. There were serious and minor injuries featuring 105 passengers, the first officer, and flight attendants. 24 passengers sustained no injuries (Aircraft accident report, 2001). The plane suffered destruction from impact forces plus post-crash fire (Aircraft accident report, 2001). Details regarding the crew operating American Airlines flight 1420 affirm that the captain and first officer were certified and qualified under the federal and company requirements. They were medically fit to conduct the flight with no tangible evidence of pre-existing conditions that would have adversely altered their performance. They were placed in charge of an equipped, certified and well-maintained aircraft with no evidence to suggest pre-existing failures of the engine and the entire system (Aircraft accident report, 2001). All decisions and outcomes were thus dependent on the flight crew soon after the departure. The accident was prompted partly by human mishap.The findings suggest that the initial decision to descend into the terminal area was marred by an approaching thunderstorm. However, the crew were rational enough to imagine that they would reach that particular area before the thunderstorm (Aircraft accident report, 2001). The weather factor poses a potential threat to the safety of the entire flight. But decisions regarding a last minute change of course of action would only happen when there is

Effective Business Planning Case Study Example | Topics and Well Written Essays - 1250 words - 2

Effective Business Planning - Case Study Example The organization has engaged effective organizational strategies by differentiating, developing effective marketing plans and penetrating the market through effective management of both people and resources. Mattel is a global toy manufacturing company that has numerous branches across the world. The company initially started with the goal of becoming a global leader in the toy manufacturing industry and to remain in this position indefinitely. However, the market environment is composed of many unpredictable limiting forces that act as barriers to market entrants and expose the organization to severe business forces that threaten survival in this market (Dressler, 2004). Mattel’s experience environmental threats, competition, ethical challenges and market fluctuations that became big threats to its survival in the market. The ability of the organization to maintain its current position today can be attributed to its ability to overcome its challenges and take advantage of the opportunities in the market while still remaining innovative in a world of changing technology. Mattel was founded back in 1945 when its main product was picture frames on a retail basis. The company later turned to the toy industries after recognizing this as a better market with higher profits and more customers. In 1960, the company became a publicly owned company and its sales remained high making it maintains its position as the world’s largest toy company. The company now has its roots in design, manufacture, and marketing of family products. The company owns more than 8 company brands and has differentiated to over 36 countries and now markets its products to over 150 nations. One of the strategies that Mattel has employed in surviving in the competitive market is the use resource and people management strategies. The company has remained strong in acquiring the right employees and leaders within the organization.

Exercise metabolism Research Paper Example | Topics and Well Written Essays - 1000 words

Exercise metabolism - Research Paper Example These studies give an insight on how nutrition affects exercise performance and metabolism. They have different results and findings. However, all of them are geared towards understanding the connection between nutrition and exercise. Nutrients included in these studies include both artificial and natural nutrients. The paper also ensures gender balance because exercise metabolism and performance is different between men and women. Hence, it looks at findings of research done on women. Human beings have different capabilities to exercise. The capability of a human being to exercise is dependent on the biological ability of his or her body to change chemical energy in the skeletal muscle to mechanical energy. Adenosine triphosphate is the chief chemical energy source in skeletal muscles. During exercise, it is characteristic of ATP storage to be depleted fast if it is not quickly replenished. This is mainly caused by the increased demand for ATP resulting from exercise. In many scenarios, when exercising, ATP need and availability are exactly balanced. AT storage is also upheld. Hence, ATP providers in contracting skeletal muscles which are known as metabolic pathways quickly react to the high demand for ATP. What determines ATP demand? ATP demand is determined by the contraction rate of skeletal muscles and the power yield during exercise. Metabolic pathways are described by the enzymes that digest ATP in an exercise session. These enzymes include ATPase, potassiu m transport, and calcium transport ATPase, and actomyosin ATPase. These enzymes are related to the contraction – relaxation cycle (Hargreaves & Lawarence, 1). Homeostasis is key for the proper functioning of the human body, be it during exercise or at rest. Thus, ATP consumption must equal ATP use for homeostasis to be maintained. Diet is a paramount manipulator of the skeletal muscle utilization of ATP when exercising and recovering

Microbiological transformation of steroids

Microbiological transformation of steroids 1. Introduction 1.1. Microbiological transformation of steroids. Steroids are small organic molecules that are synthesized in steroidogenic tissues and act on target sites to regulate a cascade of physiological functions [1]. Examples of natural occurring steroids include: sterols, steroidal saponins, cardioactive glycosides, bile acids, corticosteroids and mammalian sex hormones [2]. They are based on the steran skeleton which is composed of three six-carbon ring units and one five-carbon ring unit. The rings are labelled A, B, C, and D beginning from the far left (see fig. 1). In naturally occurring steroids, all four rings are in the chair conformation [3] with rings B, C, and D in trans- configuration with respect to each other. For rings A and B the position of the C-19 methyl group attached to C-10 and the hydrogen attached to C-5 determines the structure and their cis-/trans- configuration. Overall, neighbouring substituent are trans- if they are diaxial or diequatorial like in fig. 1a, and are cis- if they are axial-equatorial (fig. 1b). However, the two methyl groups attached to C-10 and C-13 are always axial in relative to rings B and D, with C-10 substituent being the conformational reference point [3]. Hence, the 5ÃŽ ±- steroid skeleton (see fig. 1a) is in the trans-trans-tans- configuration, and thus is broadly planar. The knowledge of the stereochemistry of steroid molecules is highly significant in understanding its biotransformation reactions which is the basis of this study. Steroids represent a class of natural products with diverse therapeutic properties. It has been observed that minor changes in the molecular structure of steroids can affect their biological activity [4,5]. Hence numerous research have been conducted to improve the activity of existing steroid compounds and to synthesize novel steroidal compounds with pharmacological activity, and thus the most significant area of these research is the transformation of steroids using biocatalysts. Biotransformation could be defined as the modification of an organic compound into a recoverable product by chemical reactions catalysed by enzymes originating from a biological system [6]. It should be noted that the organic compound which is the substrate is not involved in the primary or secondary metabolism of the biological system concerned, and thus distinguishes this process from biosynthesis. The biotransformation of steroids is one of the most important microbial processes that are highly regio- and stereospecific, involving chemical modifications (e.g. oxidation, reduction, hydrolysis, isomerisation, epoxidation, etc.) to the parent steroid which are catalysed by the microbial enzymes. In addition, the features which govern their regiospecificity differ from those controlling chemical specificity, and so it is possible to obtain biotransformation at centres that are chemically unreactive [6]. For example, in the study conducted by Peterson and Murray using Rhizopus arrhizu s, it was observed that progesterone was hydroxylated at C-11 which is an ureactive site in this steroid molecule [7]. Therefore, these characteristics alongside the rapid growth and high metabolic rates of microorganisms give biotransformation reactions an advantage over conventional chemical processes as a tool in the production of therapeutic agents (e.g. anti-inflammatory, diuretics, anabolic, contraceptive, anti-cancer, anti-androgenic, postgestational etc.) in the pharmaceutical industry. The ever growing research into the study of microbial transformation of steroids have led to newer technology in this area of science such as: genetically modification of microorganisms to improve their steroid transforming capabilities, the immobilization of whole cells or isolated enzymes in a suitable matrix for repetitive economic utilization of the enzymes, manipulation of culture media to improve product yields by the use of enhancers e.g. cyclodextrin, and the improvement of the solubi lity of substrates are insoluble (or sparingly soluble) in water [8]. Furthermore, the advances in microbial steroid biotransformation have led to the discovery of new microbial reactions and novel metabolites which may be of interest within academia and clinical medicine. 1.2. The mechanism of Hydroxylation The hydroxylation of a compound is a very important metabolic process, in humans; this process is catalysed by cytochrome P450 enzymes and results in products with a higher polarity than the parent compound, and thus aiding its excretion from the body [1,3]. The process of hydroxylation, involves the conversion of a carbon-hydrogen to a carbon-hydroxyl bond, and when catalysed by the enzyme hydroxylase, the reaction is more regio- and stereospecific in contrast to the conventional chemical process [8-12]. As a result, microbial hydroxylation is rather used for the synthesis of hydroxysteroid. Fungal hydroxylation of steroids continues to be the focus of attention at different levels of research and product development. In spite of its popularity this process is not fully understood because few studies have been conducted on the hydroxylase enzyme due to the difficulty in isolating this enzyme [10,11]. However, most studies have shown that the cytochrome P450 enzyme is also responsible for steroid hydroxylation in filamentous fungi [9-11,13,22]. Cytochrome P450 (CYP 450) enzyme is an iron-haem system which carries out a wide range of biocatalytical transformation. These enzymes are also known as monooxygenases because they transfer one atom of molecular oxygen to an organic substrate. The catalytic mechanism for this reaction involves the binding of the substrate to the active site of the enzyme and then the displacement of a water molecule (see fig.2). This is followed by a reduction of the iron in the CYP 450-haem complex to its ferrous state (Iron II) by an electron transfer. The ferrous state then binds to molecular oxygen to form a ferrous-dioxy (Iron (III)-OOH) species. This species then loses a hydroxyl anion to form an iron (IV)-oxygen radical. This radical may withdraw a hydrogen atom from the substrate to generate a carbon radical and an iron (IV)-hydroxyl species. The carbon radical then accepts a hydroxyl radical from the iron (IV)-hydroxyl species to form a hydroxylated product and iron (III). A simple general reaction equation for this process is summarised below: (where R represents the substrate and NADPH is the electron transferring species). RH + NADPH + H+ + O2 → ROH + NADP+ + H2O In other to fully understand the mechanism of fungal hydroxylation of steroids, the relationship between the structure of the CYP 450 hydroxylase enzyme and its regio- and stereoselective characteristic has to be defined. However, as mentioned earlier not much studies have been conducted on the structural features of this enzyme, and so active site models was developed to grasp the concept of the regio- and stereoselective outcome of microbial hydroxylation reactions. The first model, postulated by Brannon et al suggested the possibility for a steroidal substrate to be bound by a single steroid hydroxylase in more than one orientation due to two- sites binding, which could result in hydroxylation taking place at more than one position given the appropriate geometrical relationship between the active site of the enzyme and the carbon atom of the substrate undergoing the reaction [9,14]. These four orientations are represented as normal, reverse, inverted and reverse inverted (see fig. 3) and has been observed in the metabolic handling of 3ÃŽ ²-hydroxy-17a-oxa-D-homo-5ÃŽ ±-androstan-17-one by a filamentous fungus; Aspergillus tamarii [15]. The other model, Jones model takes into account only the normal and reverse binding orientations [6]. It requires the existence of three active centres on the steroid hydroxylase enzyme. These active centres have dual roles and could act both as a binding site or a hydroxylating site [16]. However, these roles are mutually exclusive, and so hydroxylation would occur at the closest nuclear centre to the steroid. Hence the enzyme-substrate interaction proposed by Jones would suggest a triangular location with an approximate spatial correspondence to C-3, C-11 and C-16 atoms of the steroid nucleus [6] (fig. 4). This model could not explain the hydroxylation reactions by some microorganisms. Therefore another theory was developed by McCrindle et al using both models above and taking into account the 3- D nature of the steroid compound and hydroxylase enzyme [17]. In this model, the steroid ring acts as a planar reference point (fig. 5). Binding site A favours oxygen atoms below the plane of the ring and hydroxylation is alpha. Binding site B is similar to A but can also hyroxylate alpha (axial or equatorial) or beta (equatorial) atoms. Whereas, binding site C binds preferentially to oxygen atoms above the plane of the steroid ring and hydroxylate with -beta orientation. Overall, this model tends to fit the hydroxylation pattern of most microorganisms. The hydroxylation outcome of some steroids can be predicted based on the oxygen functions or directing groups on the steroid skeleton. As a rule of thumb mono- oxygenated substrates are dihydroxylated and their transformation products are often in low yields [16]. This is as result of the presence of one oxygen function on the steroid compound making it less polar and thus decreasing its solubility which hinders its permeation into the microbial cell. In addition to this, the presence of only one oxygen function allows the steroid to bind to the enzyme at only one centre, thereby increasing its rotation and oscillation about the active site which makes it more likely to be dihydroxylated. Whereas, di- oxygenated substrates are monohydroxylated because the presence of two oxygen functions reduces the chance of multiple hydroxylations due to the reduction in the possible number of binding orientations [16]. Furthermore, the presence of two binding oxygen groups increases the rate of r eactivity of microbiological transformation as the increased substrate polarity improves solubility and thus permeation into the cell membrane of the microorganism is very likely. A wide variety of organisms have shown this pattern of hydroxylation with a wide range of substrates [15,16]. Hydroxylated steroids possess useful pharmacological activities, for example, C-11 hydroxylation is regarded as essential for anti- inflammatory action, and 16ÃŽ ±- hydroxylated steroids have increased glucocorticoid activity [8,12]. Hence the steroid industry exploits the use of 11ÃŽ ±-, 11ÃŽ ²-, 15ÃŽ ±- and 16ÃŽ ±- hydroxylation mainly for the production of adrenal cortex hormones and their analogues [8]. A range of microorganisms have been observed to affect this type of hydroxylations. For example, 11ÃŽ ±- hydroxylation is performed using Rhizopus sp. Or Aspergillus sp., Cuvularia sp. or Cunninghamella sp. and Streptomyces sp. generates 11ÃŽ ²- and 16ÃŽ ±- hydroxylations respectively [8,18]. Further research has shown other hydroxylations (e.g. 7ÃŽ ±-, 9ÃŽ ±- and 14ÃŽ ±- hydroxylations) of having the potential for industrial exploitation [18]. 1.3. The mechanism of Baeyer- Villiger Oxidation Baeyer- Villiger oxidation is the oxidative cleavage of a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters and cyclic ketones to lactones [19,20]. The mechanism of this chemical process was originally proposed by Criegee [19]. It involves a two step process: a nucleophillic attack of a carbonyl by a peroxo species resulting in the formation of a Criegee intermediate, which then undergoes rearrangement to the corresponding ester. Commonly used peracids or oxidants include: m-chloroperoxybenzoic acid, hydrogen peroxide, peroxyacetic acid and trifluoroperoxy acetic acid. This chemical process is highly significant, because the products generated are compounds which are intermediates in the synthesis of natural products or bioactive compounds. However, the oxidants used in chemical Baeyer- Villiger oxidation (BVO) are expensive and hazardous and also the reaction generates a large amount of waste products [4]. Hence biological (or enzymatic) BVO offers a green er approach for the production of chiral lactones. Biological Baeyer- Villiger oxidations are mediated by flavin- dependent monooxygenase enzymes i.e. Baeyer- Villiger monooxygenases (BVMOs) [19,21,22]. As a result of the versatile nature of flavoproteins [19], BVMOs have been shown to perform a variety of catalytic reactions including BVO of steroidal systems. The mechanism of microbial Baeyer- Villigers oxidation (fig. 6) is based on results obtained with cyclohexanone monooxygenase (CHMO) isolated from Acinetobacter calcoaceticus [19,22]. This enzyme was shown to possess flavin adenine dinucleotide (FAD) as a prosthetic group and was also found to be dependent on NADPH and oxygen. The enzymatic process is initiated by the reduction of the tightly bound FAD by NADPH followed by rapid oxidation by molecular oxygen to produce flavin 4a- peroxide anion, which acts as the oxygenating species. Nucleophillic attack of the substrate carbonyl group by the flavin 4a- peroxide anion results in the Criegee intermediate. This intermediate then undergoes rearrangement to form the product lactone and 4a- hydroxy- flavin. The catalytic cycle is terminated by elimination of water to form FAD and the release of the product and co-factor. It should be noted that the mechanism for microbial BVO based on CHMO serves as a model for other BVMOs. However, ther e are some differences such as the co-factor NADPH can be replaced by NADH and the prosthetic group FAD can be replaced by FMN [19]. Overall, there are no significant changes to the mechanism. Microbial Baeyer- Villigers oxidation is highly regio- and stereoselective [4,19-22] and as result it is commonly utilized for the biotransformation of steroidal compounds. It has also been shown in various studies, the ability of microbial BVMOs to attack the different ring systems of the steroid skeleton. Glomerella fusarioides was observed to biotransform eburicoic acid through an attack on the ring- A system by way of BVO to form a lactone, followed by a ring- cleavage to produce carboxylic acid [19]. In addition, 3-ketosteroids were observed to undergo Baeyer- Villigers oxidation with an isolated Baeyer- Villiger monooxygenase enzyme from Pseudomonas sp. attacking the C-3 ketone group on ring- A [4]. Ring- B lactone formation has also been observed in the steroid system using tomato cell suspension cultures to produce 24- epibassinolide [19]. Ring- D lactonization is very common and has been demonstrated by quite a few fungal species such as Pencillium sp., Cylindrocarim sp., M ucor sp. and Aspergillus sp. These fungi were able to biotransform progesterone to testololactone by way of Baeyer- Villigers oxidation via the intermediate steroid androst-4-ene-3,17-dione [19]. So far, ring- C lactonization has not been observed, although studies have been conducted to view this ring attack but none have proven its possibility [4]. Overall, several research have been undertaken and are still been conducted to explore the catalytic repertoire of Baeyer- Villiger monooxygenase enzymes, and these studies have shown the ability of this enzyme to catalyse the oxidation of 3- keto and 17- keto steroids with full control of the regiochemistry of the produced lactone thus allowing its application as an alternative to the conventional chemical process. 1.4. The mechanism of alcohol oxidation Alcohol oxidation is an important reaction in organic chemistry. It leads to the production of aldehydes or carboxylic acids from primary alcohol and ketones from secondary alcohol. Tertiary alcohols are resistant to oxidation because it is impossible to remove a hydrogen ion or add an oxygen atom to the compound without breaking the C-C bond. The commonly used reagents for the oxidation of alcohol are Jones reagent, potassium permanganate and chromium- based reagents. However, the oxidation of primary alcohols to aldehydes creates a problem for the organic chemist because aldehydes are not stable when produced in the conventional chemical oxidation process thus the use of microbial cells is preferred to overcome this problem [22]. The enzymes used in the oxidation of alcohol by microorganisms are alcohol dehydrogenases (ADH) which are dependent on the co-factors NAD+ or NADP+. The mechanism of this reaction consists of a series of equilibrium where the hydride from the alcohol subs trate is transferred to NAD(P)+ in the ternary complex enzyme- NAD+- alcohol complex [22]. In humans, this process is carried in the same fashion and is extremely important for several endogenous as well as drug metabolism. Therefore, microorganisms could serve as models for human metabolism using this process. An unprecedented level of regioselctivity of microbial oxidation of the alcoholic group in bile acids has been observed [23]. Some fungal species are known to have the ability to oxidise the C-3 and C-17 hydroxyl groups of steroidal compounds. Aspergillus tamarii has been shown to possess the enzyme 3ÃŽ ²- hydroxy- steroid- dehydrogenases which catalyses the 3ÃŽ ²- hydroxyl group to a C-3 ketone [5]. Oxidation of the 17ÃŽ ²- hydroxyl group has also been observed in a number of fungal species e.g. Penicillium sp., Aspergillus sp. and Mucor sp [24,25]. In general, a number of microorganisms have shown the ability to oxidise the alcohol groups on a steroid compound to generate t he ketone analogue, which could serve as an intermediate in the synthesis of lactones. 1.5. The mechanism of carbonyl reduction The reverse reaction of oxidation is reduction. It involves the transfer of one hydride ion to the carbonyl group. In conventional chemical reaction, the catalysts commonly used are sodium borohydride (NaBH4) and Lithium aluminium hydride (LiAlH4), aldehydes are easily reduced to primary alcohols using these catalysts. However, the high stereoselective reduction of ketones to chiral secondary alcohols is better performed with microbial enzymes [20,22]. This process is catalyzed by alcohol dehydrogenases (ADHs), requiring the co-enzymes NADH or NADPH which transfers the hydride ion to the Si- or Re- face of the carbonyl group resulting in the formation of the corresponding (S)- or (R)- alcohol [22,25]. Microbial reduction of ketones to secondary alcohols normally proceeds in accordance with Prelogs rule to give secondary alcohols in the main (S)- enantiomer [25,26]. However, only a very limited number of microbial enzyme (ADHs) is available to allow anti- Prelog activity and have bee n demonstrated in the fungus Myceliophthora thermophila [27]. The ability of microorganisms to reduce the carbonyl groups on steroid compounds was reported in 1937 by Mamoli and Vercelloni who described the reduction of the 17- keto group in androst-4-ene-3,17-dione to testosterone by Saccharomyces cerevisiae [25]. Since then this process has been demonstrated for a wide variety of substrates and microorganisms of different species. Carbonyl reduction often accompanies other reactions in steroid biotransformation, and thus acts as one of the processes in the production of hydroxysteroids. 1.6. The microorganism: Myceliophthora thermophila Thermophilic fungi are among the few fungal species of eukaryotic organism that are able to survive at temperatures as high as 60 62oC [28]. However, Cooney and Emersons definition of thermophilic fungi is: fungi that have a growth temperature minimum at or above 20oC and a growth temperature maximum at or above 50oC [29]. These fungi have a widespread distribution in both tropical and temperate regions, inhabiting various types of soil and places where decomposition of plant material and organic matter occur thus providing the warm, humid and aerobic environment which are the basic conditions for their development [28,29]. The enzymes of thermophilic fungi have been studied to explore their contribution in biotechnology, and these studies have identified a remarkable range of extracellular enzymes (e.g. proteases, lipases, ÃŽ ±-amylases, glucoamylases, cellulases, cellobiose dehydrogenases, xylanases, ÃŽ ±- D-glucuronidase, polygalacturonase, laccases, phytase and D-glucosyltransf erase) and intracellular enzymes (e.g. trehalases, invertases, ÃŽ ²-glycosidases, lipoamide dehydrogenases, ATP sulfurylases and protein disulfide isomerases) [28]. The majority of these enzymes are appreciably thermostable which have resulted in its application in sugar and paper industries [30]. So far only two studies to date have been conducted to investigate the steroid biotransformation abilities of thermophilic fungi. The first study used the thermophilic filamentous fungus, Rhizomucor tauricus and it was observed that all transformations were oxidative producing mono- and dihydroxylated products with allylic hydroxylation been the predominant route of attack on the steroid compounds [30]. The second study was conducted using Myceliophthora thermophila [27] on which this present study is based. Myceliophthora thermophla is a thermophilic filamentous fungus classed as an ascomycete within the phyla of fungi [28]. It has another name which is sometimes used, Sporotrichum (Chrysosporium) thermophile [28,29]. However, M. thermophila is the sexual (telomorph) stage of the fungi, while Sporotrichum (Chrysosporium) thermophile is the asexual (anamorph) stage [28]. Its main habitat is in the soil and it is found in the following countries: USA, Canada, India, UK, Japan and Australia [29]. But this fungus can grow on simple media containing carbon, nitrogen and essential mineral salts such as Czapek- dox agar (CDA). The optimum growth temperature for M. thermophila is within the range 45 50oC [28]. It grows rapidly on CDA at 45oC, producing colonies that vary in surface texture from cottony to granular and its colour changes from white to cinnamon brown [29]. This fungus has also been observed to generate extracellular enzymes such as laccases, xylanases, cellulases and phytase wh ich have been exploited for use in the food industry and as biocatalyst in biotechnological processes [27]. This present study is a continuation of the research into steroid biotransformation by M. thermophila. Previously, a series of steroids (progesterone, testosterone acetate, 17ÃŽ ²-acetoxy-5ÃŽ ±-androstan-3-one, testosterone and androst-4-ene-3,17-dione) were incubated with this fungus, and a wide range of biocatalytical activity was observed with enzymatic attack at all four rings of the steroid nucleus and the C-17ÃŽ ² side- chain. This fungus demonstrated an unusual ring- A opening following incubation of the steroid 17ÃŽ ²-acetoxy-5ÃŽ ±-androstan-3-one, and thus generating 4-hydroxy-3,4-seco-pregn-20-one-3-oic acid. It was also identified to be the first thermophilic fungus to cleave the side- chain of progesterone. M. thermophila also demonstrated reversible acetylation and oxidation of the 17ÃŽ ²- alcohol of testosterone [27] (fig. 8). Further investigation into the diverse biocatalytical activity of this organism has led to the incubation of six saturated steroids namely: 17ÃŽ ²-hydroxy-5ÃŽ ±-androstan-3-one, 5ÃŽ ±-prgnane-3,20-dione, 3ÃŽ ²-hydroxy-5ÃŽ ±-androstan-17-one, 3ÃŽ ±-hydroxy-5ÃŽ ±-androstan-17-one, 5ÃŽ ±-androstan-3,6,17-trione and 5ÃŽ ±-androstan-3,17-dione with M. thermophila 1.7. Hypothesis The proposed hypothesis from previous study is outlined as follows: * Presumed lactonohydrolase activity evident from the isolation of an open lactone ring. * Enzymes responsible for the reduction of C3 ketone to a 3ÃŽ ±- alcohol and hydrogenation of the C-4-C-5 alkene are induced by progesterone. * Organisms ability for reverse metabolism, which is evident from the acetylation of testosterone to generate testosterone acetate and the reduction of the C-17 ketone of androst-4-ene-3,17-dione to produce testosterone which further undergoes acetylation. * Preference for stereochemistry of hydroxylation with attack at axial protons (6ÃŽ ², 7ÃŽ ±, 11ÃŽ ², 14ÃŽ ±). Therefore, the main aim of this study is to observe the effect of saturated steroids on the biocatalytical activity of Myceliophthora thermophila CBS 117.65 and to prove the hypothesis from the previous study.

Year without Oil :: essays papers

Year without Oil OPEC Oil Embargo There are several things that come to mind when presented with the picture and topic, but the one that stands out most is shortage. However, shortage is an ironic word to use for it. It wasnÕt really a shortage in the fact that the world is out of oil, which being a non-renewable resource will be one day, but it was an incredible 130% increase in price by OPEC, Organization of Petroleum Exporting Countries. This forced the petroleum market to head into a tailspin. OPEC, started by the major oil producing countries in the Middle East, was designed to give price control to the oil producers, instead of the oil manufacturers. Formed in 1960, OPEC was only a middleman for 10 years, but in the 1970Õs, they found the right time to drive up the price of gas. One viewpoint can say it was about time that we started paying these countries for what they were up to that point, "giving us," but from the other standpoint, OPEC is no more than a cartel and monopoly. A cartel is two or more parties, the oil producing countries, hurting an innocent third party, oil consumers. OPEC was created to hurt the oil manufacturers who were taking advantage of the oil producers, but unfortunately the one that got hurt from the agreement are the oil selling stations and us, the consumer. There are several reasons why it isnÕt the manufacturers didnÕt get affected by any of the price raises. First of all, no matter how high the price of crude oil goes, the world still has to keep buying oil products. In fact, the world is using more petroleum products now than it ever has before, and can only get it from a few manufacturers, which means a monopoly is feeding an oligopoly. Monopolies are when the economy relies on one source for all of a product, also called a trust. Monopolies are banned in the United States by Anti-Trust Laws. Oligopolies are products, that the economy relies on, that are only available from a few sources. In a large market, the oil market, these companies can raise prices for consumers and receive massive increases in their profits. "To really understand the hardships that happened in the 1970Õs, and not being around in that time, we can look at the situation we are experiencing today.

HIV/ AIDS Essay

A lot of people don’t get tested because they don’t believe something like this can happen to them until it do then they walk around miserable and feel as if life is over. Getting tested every six months makes a difference depending on how sexually active you are you might want to get tested more. I personally get tested every 3 months because my mother died from this virus and I do not want to leave my kids the same way she left me. Although you may not be that comfortable it is for the better of you that you get tested and make sure you protect the people around you. You have to think of other people when you think about possibly getting a virus that can never be reversed. This is a very tricky thing to have to tell your loved ones about you don’t want to have to sit down with your kids and tell them something like this. There are a lot of things that you will have to go through once you are diagnosed with such a virus you have to not only make sure that you stay healthy, so that you stay around for your family. We have more information on this virus meaning we can keep you alive longer you might not be able to do things the way you use to but you will be alive as long as you follow your doctor’s orders. There are still a high number of people that are not aware of this virus. It’s ashamed to the number of people that aren’t aware. There are about 12,000 people who are not aware of their status because they do not get tested. Our youth is being infected with this virus because they want to experiment with sex. There are about 57 percent of our youth that are gay or bisexual and are just going around infecting each other. Things need to change and quickly because if not we won’t have a future of healthy people. There are many types of ways people can get tested and many dif ferent places that you can go without any one finding out that you got tested as well as what you status is. You just have to have the courage to go get tested. I found it easier to go with a friend or your loved one to make you more comfortable. As long as you get tested to make sure you are safe is all that matters. Families need to inform their children on how important safe sex is we have to realize that they are going to do it anyway no matter what we say so all we can do is keep them safe by providing them with everything they need to experiment safely.

How To Avoid Costly Mistakes In Influencer Marketing With Shane Barker

How To Avoid Costly Mistakes In Influencer Marketing With Shane Barker Did you do a lot of stupid things when you were a kid? Did you get caught and yelled at? Was your #1 go-to argument: Well, my buddy was doing it first only to be told, â€Å"Well, if your friend jumped off a bridge, would you do it, too?† As a kid, there are certain people who influence and inspire you. As you get older, that doesn’t change. About 92% of consumers trust earned media, such as word-of-mouth and recommendations from friends and family, more so than any other form of advertising. The result: Influencer marketing. Today, we’re talking to Shane Barker, a digital marketing consultant who specializes in influencer marketing. He shares the top three things needed to execute a successful influencer marketing strategy, as well as pitfalls to avoid. Influencer marketing is the practice of using social media influencers to promote your brand, Website, or products Social media influencers have some type of influence over their followers, who trust and believe in them for information and guidance Don’t look at the follower count; number of followers incentivizes who is an influencer, but fake followers are used to make that happen Brands that use influencer marketing successfully include LinkedIn and LikeToKnowIt Software can be used to find influencers consider engagement rates and profiles, not â€Å"likes†; conduct research to build a long-term relationship Pitfalls to Avoid: Don’t go after the influencer with the largest following and spend time selecting and setting expectations for an influencer Measure success of influencer marketing via affiliate codes/links, Website/landing page traffic, brand mentions, engagement rates, etc. Future of Influencer Marketing: How to scale this type of marketing, develop a win-win strategy, and educate brands on how to find influencers Links: Shane Barker Shane Barker’s Email Content Solutions Global Trust in Advertising and Brand Messages LinkedIn The Sophisticated Marketer’s Guide to LinkedIn Liketoknow.it Grin Influence.co Fiverr Send suggested AMP topics and guests If you liked today’s show, please subscribe on iTunes to The Actionable Content Marketing Podcast! The podcast is also available on SoundCloud, Stitcher, and Google Play. Quotes by Shane Barker: â€Å"Influencer marketing is essentially the practice of using social media influencers to promote your brand, Website, or products.† â€Å"These people have some type of influence over their following.† â€Å"Not all engagement is good engagement. Is that an influencer you want to have your name associated with?† That’s one of the big questions is like, Oh, what do I pay an influencer? Well, it really depends. It really depends on the influencer because each one of them run their business differently.

United Nations and International Peace

United Nations and International Peace Introduction United Nations is an international organization, established in 1945 after the Second World War following the dire consequences of the First and the Second World Wars. Although the First World War led to the establishment of the League of Nations in order to promote international peace and security, it failed to prevent the occurrence of the Second World War. To overcome the flaws in the League of Nations, the United Nations was formed on 26 June 1945, when the Charter of the United Nations was signed by member states.Advertising We will write a custom essay sample on United Nations and International Peace specifically for you for only $16.05 $11/page Learn More The functions of the United Nations as stipulated in the Article 1 include maintaining international peace and security, developing friendly relations among nations, promoting international cooperation in problem solving and harmonization of the collective responsibility of the nations ( Auden, 1997, p. 50). This essay examines the role of the United Nations in maintenance of international peace and security, and its effectiveness as empowered by the charter. The United Nations Provisions The Charter of the United Nations Article 24 empowers the Security Council to exercise the functions of the United Nation. According to the International Court of Justice (2010), the United Nations members â€Å"confer on the Security Council primary responsibility for the maintenance of international peace and security, and agree that in carrying out its duties under this responsibility the Security Council acts on their behalf.† The Security Council has prerogative of determining peace and security status of the member states by ensuring that every member has equal rights of protection. The Security Council should discharge its functions as stipulated in chapters VI, VII, and XII in the Charter of the United Nations. Chapter VI of the United Nations Charter deals with Paci fic Settlement of Disputes. This chapter empowers the Security Council to call disputing parties to solve any dispute â€Å"by negotiation, enquiry, mediation, conciliation, arbitration, judicial settlement, resort to regional agencies or arrangements, or other peaceful means of their own choice† (Browne, 2003, p. 16). The Security Council identify, investigate and recommend appropriate procedures of addressing situations that may threaten the maintenance of international peace and security to the International Court of Justice (Novak, 2001, p. 5). In chapter VII, the United Nations Charter gives powers to the security to â€Å"determine the existence of any threat to the peace, breach of the peace, or act of aggression and shall make recommendations, or decide what measures shall be taken in accordance with Article 41 and 42, to maintain or restore international peace and security† (Miller, 1999, p. 67). The Security Council will use all means to make sure that all it s members are protected against any threat to peace or an aggression.Advertising Looking for essay on international relations? Let's see if we can help you! Get your first paper with 15% OFF Learn More In chapter VII, the United Nations Charter empowers the Security Council to ensure that any regional arrangements that involve maintenance of the international peace and security should comply with the United Nations purposes and principles. According to the Article 52, â€Å"the Security Council shall encourage the development of pacific settlement of local disputes through such regional arrangements or by such regional agencies either on the initiative of the states concerned or by reference from the Security Council† (Brader, 2005, p. 78). The Security Council should be updated â€Å"at all times about the activities undertaken or in contemplation under regional arrangements or by regional agencies for the maintenance of international peace and secur ity† (Smith, 2002, p. 33). Since the United Nations Security Council is responsible for the maintenance of peace and security worldwide, then any issues related to peace and security are of great concern lest they threaten peace and security of others. Effectiveness of the United Nations Political nature of the General Assembly and the Security Council hinder the effectiveness of the United Nations in fostering international peace and security. Simon (2009) argues that, ‘the United Nations’ efforts to preserve international peace and security are the most contentious aspect of its entire work, because of the inherently political nature of its role† (p. 23). The resolution of conflicts and disputes depend on the political orientation of the General Assembly, Security Council and member states thus complicating the issues. The decision to invade Iraq was formulated politically by George Bush and Tony Blair to deceive the world that Saddam Hussein had weapons o f mass destruction. Prados and Ames (2010), argue that, â€Å"the evidence indicates the decision was made very early, long before ultimatums to Iraq or other diplomatic action.† This shows that the main reason for Iraq invasion was political rather than a security reason. Another case is the cold war between the United State and Soviet Union where Baruch describes it as â€Å"the most important political and diplomatic issue of the early post war period† (2007). The split of the Soviet Union was due to political influence of the United Nations. Conclusion The main reason for the establishment of the United Nations was save the world against horrible consequences of war. Horrible experiences of First and Second World War made the world leaders to come together and think of various ways of preventing the future occurrence of war.Advertising We will write a custom essay sample on United Nations and International Peace specifically for you for only $16.05 $11/pa ge Learn More The United Nations in its Security Council arm is fostering international peace and security through legal procedures, diplomacy and military peacekeeping. With this noble responsibility, the United Nations experiences undue political pressure as they maintain international peace and security. References Auden, H. (1997). The United Nations Charter. Human Rights Journal, 22(3): 45-53. Print. Baruch, B. (2007). Cold War. Global Security. Web. Brader, S. (2005). International Relations: Peace and Security. New York. Norton. 78. Browne, M. (2003). United Nations Peacekeeping: Issues for Congress. The Library of  Congress, 6(2): 1-16. International Court of Justice, (2010). The Charter of the United Nations. Web. Miller, T. (1999). Peace Treaties and the United Nations. Chicago: University of Chicago Press. 67.Advertising Looking for essay on international relations? Let's see if we can help you! Get your first paper with 15% OFF Learn More Novak, G. (2001). The Security Council: United Nations. Journal of Human rights, 3(1): 5. Prados, J., Ames, C. (2010). The Iraq War: U.S. and British Documents Give No Indication Alternatives Were Seriously Considered. National Security Archive. Web. Simon, T. (2009). International Peace Security: Basic Charter Provisions. United  Nations Review, 34(9): 23. Smith, P. (2002). The Charter of the United Nations. The Expositional Journal, 12(1): 32-33.

How changes in the world economy since 1945 have affected room for Essay

How changes in the world economy since 1945 have affected room for maneuver of multinational firms - Essay Example Over several centuries, trade has always flowed across states, borders, and civilizations thus joining economic fortunes and acting as a channel for social practices, technologies, and ideas. International trade began to flourish at the beginning of the nineteenth century. The trade grew geographically between nations that were industrialized and in the imperial patronage, it grew between the underdeveloped peripheries and the urban centers. During the century, the average export to GDP ratio for developed economies rose to about 11% and for individual trading countries particularly in Europe, higher ratios were recorded (Gruber, 2007). This however did not last for a long time as the First World War coupled with depression of inter-war brought international trade to a halt, introduced imperial trading blocks, and increased trade tariffs substantially and other restrictions on import. Since 1945 however, there emerged far-reaching trading systems. Most countries began to trade with a large number of other countries. Regional trading became supportive of and complementary to more widespread multinational link. Even though the majority of trade took place between OECD nations, things began take a different route pretty first. These changes in the world economy since 1945 affected room for  maneuver of multinational firms. Such changes included: The Latin American and Eastern Asia industrializing economies began taking a substantial share of world trade; the liberalization in India, China as well as other developing countries, which made these countries more than ever set to intensify their trading ties beyond borders. Another change was the growing communication and transportation infrastructure, which reduced uncertainties and costs of trade according to Karlsson & Honig (2009). This growth in transportation and communication reduced significantly the investment required by multinational firms to venture in foreign economies. The crumbling of communism after 1 945 also brought very many nations into the international trading system. The formation of GATT and later WTO created a legal infrastructure, which was more accommodating than other previous systems before 1945 and the tariffs were also substantially decreased. Discussion The improvement in communication and transportation boosted the process of internationalization process of firms. Before 1945, communication infrastructure was still very poor. In 1956, the most noteworthy improvement in communication came to pass when for the first time the American telegram as well as telephone opened a telephone cable that was transatlantic by means of microwaves amplification technology. Following this advancement, multinational corporations for instance Ford began utilizing this new communication network to exchange information as well as manage operations based in other countries from their headquarters in the United States. According to Gruber (2007), though telephone cable tremendously enha nced enterprise communication after 1945 especially in urban areas, a huge portion of the world never utilized that opportunity optimally. Nevertheless, the introduction of satellite communications in the early 1980s started a new chapter in the world of multinational firms as it ended isolation and made the world a global village, multinational firms could now operate from almost anywhere in the world as communication made everything quite simple for them. The collapse of communism and the emergence of capitalism after 1945 saw many other nations accepting the American style globalization. The fall of communism gave the Anglo-American powers an opportunity to institute the system of the United Nations and establish the institutions of international economics such as the World Trade Organization (WTO). Financial collaboration was also introduced and this was a great opportunity for the multinational fir

Automobile Brake Disc and Pad Essay Example | Topics and Well Written Essays - 1000 words

Automobile Brake Disc and Pad - Essay Example However, in special cases such as in racing cars or for people with disability, hands may be used as a means of enhancing efficiency, according to Owen (2010). It is very interesting that many people still wonders how a small peddle, in the form of a car brake is able to stop a huge car in motion with just a slight press of the brake. Similarly, it is still a mystery to many people, how it happens, though people increasingly understand the working system of a car brake. Basically, when a driver presses the brakes with the help of the legs, a force is transmitted from the driver’s foot to the brakes via a fluid. However, since the car needs a much greater force than applied by the leg to stop, the car normally multiplies the force applied by the foot. The braking system then transmits the force to the car tires and consequently the tires transmit the force to the road where the friction law applies and the car stops (Erjavec, 2008). Car brakes are of two types, namely drum and disc brakes. Drum brakes is a type of breaking system that stops a car in motion by friction, when brake shoes are pressed against the drum. Drum brakes have many components that are important for its operation. These include drum, piston, wheel cylinder, return spring, brake shoe, stud, brake pads, wheel hub, and brake lining. The existence of these components makes it easy for drivers to stop vehicles easily by applying just a little pressure on the brake pedal (Gilles, 2005). Disc brakes, on the other hand, are a round, flat metallic pieces that spin together with the wheel. When brakes are applied against the wheel, a caliper squeezes the brake pads against the disc (rotor) thereby causing friction that makes the wheel to slow down and eventually stop. Disc brakes consist of different components such as brake pads, the caliper that has a piston and the rotor usually mounted to the hub. Research indicates that most modern cars are increasingly adopting the use of disc brakes fixe d in front of the wheels while others have disc brakes on all the four wheels (Erjavec, 2003). An example of a disc brake (brake rotor) commonly used on modern cars is the single-piston floating caliper. The most striking feature of this rotor is that it is both self-centering and self-adjusting. The caliper here is capable of sliding from side to side thereby making it move to the center every time the brakes are applied. In addition, since this type of disc lacks the spring to pull the pads away from the disc, the pads normally stay intact with the rotor. This is crucial since the pistons in the brakes have a larger diameter than those in the master cylinder. In case the pistons retract into their cylinders, the brake pedal might require several applications to be able to pump enough fluid into the brake cylinder so as to engage the brake pads (Gilles, 2005). The type of brake rotor one buys depends greatly on the type of vehicle that one drives, as well as the type of driving one does. For instance, carbon reinforced rotors were the most commonly used discs in racing cars such as in Formula One racing cars. This is based on its ability to get heated up to high temperatures needed for proper braking. However, this is no longer the case as it has been replaced by the carbon-fiber reinforced ceramic brake rotor, which is the most preferred for use currently in racing cars. This is attributed to its high performance on the road. For example, high performance cars such as the latest Porsche Carrera GT, Corvette ZR1, and Ferrari Enzo use ceramic

ITM301 SLP Essay Example | Topics and Well Written Essays - 500 words

ITM301 SLP - Essay Example Evidently the user-friendly structure and the dependability of the site are the major reasons why Wikipedia has become the highest ranking sites. Overall appeal Wikipedia is a professionally designed website for its simple whiteboard and well optimized content and images. The absence of promotional content also enhances its professional appeal. The article on ‘distance education’ published on the site can be taken as an example for its outstanding level of content and external link feasibility. At the same time, the well-bound internal linking structure also makes the specific article page and the entire site extraordinary. As in every case of Wikipedia articles, the ‘distance education’ also provides readers with hundreds of keywords and phrases which work as internal and external links for further research. Strengths of the site The website is rather interactive for it allows users to contribute to the content development and editing. Although it tends one to be skeptical of the reliability of the information, today inaccuracy is less likely to happen because of its strong self-control. The Wikipedia gives number of other options like contents, featured contents, current events, and random articles at the left hand side of the web pages which help users to trace required information quickly.

Supply chain management Essay Example for Free

Supply chain management Essay In this final paper for Managerial Finance I will attempt to show how the supply chain inventory management method can be affected depending on the situation of the retailer. Studying the control method for problems in inventory, which would include both, excesses in inventory as well as shortages, and hoping to minimize loss. Use of SCM as a Method of Inventory Control I have decided to do the final for Managerial Finance on the use of the SCM method as a form of inventory control, because I have worked in a business that has used many different forms of inventory control. As a manager it was one of my responsibilities to maintain inventory and observe any losses as a loss prevention issue that must be discovered. The ordering responsibility for inventory was one of my most important duties as a manager. â€Å"Supply Chain Management is a set of synchronized decision activities, utilized to effectively integrate suppliers, manufacturers, transporters, warehouses, retailers customers so that the right product or service is distributed at the right quantities, to the proper locations at the appropriate time, in order to minimize system wide costs while satisfying customer service level requirements. (Misra, 2010) Finding different options for inventory choices as well as finding prices that reflects a profit for the company was primary reasons for me to research the available possibilities in inventory. Deciding a price for acquiring inventory is an important aspect of making a determination in product for any company striving to make a profit. An important aspect of inventory is the amount of inventory that needs to be ordered, as over ordering or under ordering can be just as problematic for a company. A company that over orders does ot receive profit, because they have put out too much money without a return on that investment, will not make a profit. A popular product may sell very well for a company, but an overabundance of product means that the remaining product after sales may end up being a loss if sales do not again pick up. Under ordering can be just a big of a problem for a company because when customers start coming in for products that are not on the shelves it leads them to find alternate sources for their purchases. Under ordering can also create problems when it comes time to do a secondary order. The initial under ordering of product can lead even the most cautious of managers to second guess their ordering process. The initial under order leads a manager to think that they need to order more of the product to compensate for future sales of the product. The main problem that comes from this common over reaction is that the company lost out on sales on the initial order so tried to compensate by ordering more of the product on their new order. There may have been an increased demand on the first day of sales that may not (usually not) return when the manager orders more stock. The ability to make an initial determination as to the proper inventory can be a deciding factor on a profitable business and an unprofitable one. SCM or supply chain management is a process that refines the process in which managers make their decisions for the products and services that the company offers. SCM is a way for a company to find the products that they offer to their customers. â€Å"The Supply Chain management (SCM) is defined by the Supply Chain Forum (SCF) as the integration of key business processes from end user through suppliers that provide goods, services and information that add value for customers. (Assey, 2012) Supply chain management takes the production of a manufacturer and presents it to a supplier; the supplier then presents those products to the retailers which in turn provide those products to the customers. Choosing the supplier that gets the best deal from the manufacturer is going to give the most profit for the retailer selling the product to their customers. The process of supply chain management can actually merge retailers with supplier just as suppliers merge with the manufacturers. Some companies choose to use various different suppliers for their products while other companies choose to use a single supplier for their product. Personally I worked for a video game company called FuncoLand which was purchased by a company called Babbages, which merged with Electronics Boutique. After the merger the name of the company was changed to GameStop which is now the largest video game retailer in the United States. The thing that makes this important to this paper is that when FuncoLand was purchased by Babbages the supply chain changed. The change in the supply chain meant that all orders must be relooked at to insure the same profit levels for products that GameStop enjoyed. The single supplier for GameStop was replaced by the numerous different suppliers of Babbages. Every item of inventory needed to be checked to make sure they reflected a price that was going to produce profit for the merged FuncoLand and Babbages stores. Inventory charts were created and every store of both needed to inventory all items listed so that they could be compared with the new companies overall stock as well as profit ratios. Once the inventories of both companies were done there was a coordinating effort by upper management to determine prices of available product as well as the suppliers that were going to deal which each stores location. The numerous different suppliers made each location different in their ordering and inventory procedures. As could be expected this made it very difficult for these merged companies to be individually managed by the district and upper management. Each individual store was looked at by the store managers and was expected when issues arose to contact headquarters immediately. The buyout of these two merged companies by Electronic Boutique turned out to be a blessing in disguise for all involved. Electronic Boutique used a single supplier had dealt with the same supplier for years and had already worked out their profit ratios (including the purchase cost of the two companies) and store management once again needed to inventory their entire product for the new owners. The name was changed to GameStop and all store locations now used the same supplier and the prices for each store location were set by upper management. Ordering was done automatically based on the initial stores inventory counts and the new POS systems. While I understand there is an alternate definition for POS in this instance it refers to â€Å"point of sale†. The point of sale system was built using the store’s inventory, and orders for products were made, when the sales reached a certain level. Once a product reached a certain level of sales and did not continue to sell the item was automatically removed from the automatic reorder listing. The product would not be reordered into that store location unless it was a pecial order done by the stores management and usually had to be presented with a reason for the order to be made. In the four years that I worked for GameStop I only ever had to use this feature one time. A customer wanted Final Fantasy 7, new and unopened, and this was well over a year after the initial release of the game. The suppliers notified the upper management that they could do this, and I placed an order for the product as a full pre-sale, which means that the money was available to GameStop before the product was available to the customer. Being the only time this issue ever arose for me while working at GameStop it was an interesting learning experience about how a supply chain management process works. â€Å"The descriptive model presented is useful in settings where organizational structure and the supply chain are needed to support sustainable products and processes and whose success is facilitated by establishing strategic partners, especially those that make possible economies of scale†. Pullman Dillard, 2010) Since one of the primary reasons for using supply chain management is to reduce inventory and cost for a company, GameStop has achieved what neither FuncoLand nor Babbages were able to because their use of a single supplier made achieving profit that much more possible for the mangers making their store orders. â€Å"Most of the decline is due to more efficient cash and inventory management†. (Ross, Westerfield, Jaffe, Jordan, 2010) The main purpose of examining the supply chain management method is insuring that the retailer gets the best uses of their supplier(s). Minimizing shortages, while acquiring profits, in an attempt to optimize the proper supply for each location, is another purpose of using supply chain management. The strategy can be difficult to implement for those unaware of the procedures. I must admit that I did not realize the purpose (or the concept) of supply chain management, at the time I worked for GameStop. Looking back at my time at GameStop has led me to a new appreciation for the business that was built off of the back of FuncoLand.

An Overview of Surgery

An Overview of Surgery Surgery Overseas Surgery is an antique medical specialty, which uses operative labor-intensive and influential procedures on a patient to look into and treat a pathological state such as injuries or diseases. Surgery is an expertise consisting of a corporal intervention on muscle, and tissues. A surgery helps in improving bodily function and appearance and also to repair unnecessary ruptured areas for instance a perforated ear drum. A surgical procedure is an act of performing a surgery. Human beings and animals are subjects or patients on which a surgery is performed. A person who practices surgery is known as a surgeon. People described as surgeons are usually podiatrists, veterinarians, dentists (usually referred to as maxillofacial and oral surgeons) and physicians. A surgical team consists of a surgeon’s assistant or a surgical assistant, a circulating nurse, a surgeon, a surgical technologist and anesthesia provider. A surgery process spans minutes to hours. However, it’s naturall y not a continuing or cyclic treatment or type. A surgical process that can be programmed in advance because it doesn’t include a medical emergency is known as elective surgery. Some of the common elective surgeries or procedures include plastic surgery and cosmetic surgery. As a universal rule, a process is well thought to be surgical when it includes closure of a formerly sustained wound or cutting of patient’s tissues. . Nations such as Argentina and South Africa present the same high standards of surgery as hospitals back in the United States, although with important differences in price- charge savings can be enormous, the surrounding can be more comfortable and there’s also less arguing with the insurance company to cover up the costs of surgery. Procedures such as endoscopy or angioplasty may be deemed as an operation if they include common surgical settings or procedure. These procedures include anesthesia, use of sterile environment, typical surgical instruments, suturing or stapling and antiseptic conditions (Bhatia 21). There are many types of surgeries. Surgical processes are normally characterized by procedural types like invasiveness degree, unique instrumentation and urgency; Principle Based:The type of surgery that is exploratoryis usually performed for confirming or aiding diagnosis. Previously diagnosed condition is treated by a therapeutic surgical treatment. Through organ of body: The performance of s surgery on the organ of structural systems, this could be cashed out involving the system’s organ and the involvement of tissue of the organ. For instance; surgery through gastrointestinal (which is done within the region of digestive and the organs that are accessory), surgery of orthopedics (which is conducted on bones and muscles) and cardiac surgery (which is performed on the heart) Through invasiveness scale:modestly surgery that is invasive includes external little incisions that are to be included in the objects that are miniaturized inside the structure of the body and cavity, like laparoscopic or surgery angioplasty. By differentiating to that, a laparotomy or process that is open surgicalneeds a great incision for the area of interest to access (Bhatia 9). Through procedure type: amputationincludes cutting off body parts, usually a digit or limb; castration is also an instance.Resectionis the elimination of part of or all internal organs or body parts.Replantation includes reattaching the severed parts of the body.Reconstructive surgical treatmentinvolves restoration of a deformed, mutilated or injured or body area.A surgerywhich is Cosmetic always is initiated to advance a usual and otherwise structure. Deletion comprises of the cutting out or removal mainly of an organ, tissue or the other patient’s body parts. A surgery of Transplantation comprises of the body organs substitution with that of different inclusion from other dissimilar being i.e. of human (other living things also) within the patient. It also includes the removal of animals or human beings body organs to conduct a kind of surgery that utilizes organ transplantation (Sullivan 10). Through timing basis:The surgery named ‘elective’is done to repair the situations of a threatening i.e. non-life, and is conducted by the consent and patient’s appeal to the doctors matter of subject and facilities of surgical availability.Another surgery named ‘Emergency’ is a type of operation, which must be implemented without delay to, limb, lifesaving and capacity functionality. Apartially surgery i.e. electiveis the only type that must be conducted to evade death and disability that can be permanent. This type of surgery, for a little time, can be postponed. By using equipment and tools: The surgeryinvolving the use of lasersis known as Laser surgery. Laser can be used for the cutting of tissue as a scalpel substitute or instruments of surgery related to it. The surgery by the name of ‘Microscopic’ involves utilization of microscope i.e. functional for the basic partitioning. This functional microscope is used to see structures that are very tiny. The surgerynamely ‘Robotic’ utilizes a robot for surgery such as the surgical system ‘Zeus’ in which the devices are governed under the surgeon’s sway (Aston, Douglas and Jennifer 12). Modern surgery is always completed in an operating theater. It is done using an operating table, surgical instruments for patients and other equipments at the hospital. The theory of aseptic technique governs the procedures and environment used in surgeries. The aseptic technique includes the strict severance of sterile (which is free of microorganisms) instruments from contaminated or unsterile instruments (Klingensmith, 6). This means that there is average-quality proof that usage of many gloves layers compared to only a single gloving during a surgery process reduces blood stains and perforations on the skin, representing a decline in percutaneous spotlight incidents (Earle 45). The surgery process is always long. The process includes; an opening is made in order for accessing the spot surgically. The vessels of Blood are perhaps being clamped or cauterized for the prevention of bleeding. The usage of retractors helps to keep incision open and to expose site. Due to advancement in the spot surgically can include a number of abdominal surgery incisions and dissection layers (Norton 67). To skin traverse, incision is used within muscles three layers, peritoneum and from that the subcutaneous tissue. Considering sure instances, bones are further amputated always to contact further the bodies inside portion; for instance sternum cutting for surgery of to unlock up rib cage or cutting the cranium for brain surgery. While in surgery safety and health are used to prevent further distribution of the diseases and also prevent infection. Using a head hat, the surgeon is able to remove hair from the eyes and hair. In order to prevent germs from getting into operated bo dy, wrists, forearms and hands are always washed thoroughly. Gloves are always placed onto the hands. To stop any contamination, a PVC apron is always worn. On the situated region of the sick person’s body, a yellow substance- normally an antiseptic iodine result is coated lightly. This stops diseases and germs infecting regions of the body performed on (Jarrell 23). . The surgery work may well involve: Excision – cutting out a tumor, organ, or other tissue. Ligation– tying off blood tubes, vessels, or ducts. Resection– fractional elimination of any organ or other physical structure. Realignment reduction – It is the body’s components movement or the realignment for bringing it back to its original shape. For instance, broken nose diminution includes the manipulation of body cartilage and from their shape displacement of the bone restoring to inventive position of it to normally repair airflow and aesthetics; Tissues, organs reconnection etc. predominantly detached if. Organs and tissues reconnection like reconnection of intestine inclusively. Stapling internally and may be suturing applied. Correlation surgically between various vessels of blood or tubular or void components for example, an intestine loop is referred to asanastomosis. Prostheticinsertion sections required when. Screws and pins used for holding and bones may be used to set. Bone parts may well be reinstated involving the various body parts or shaft prosthetic. The insertion of plate sometimes used for the replacement of the spoiled skull part. Hipnon-natural substitution universally has become common. Heart or valves pace makersperhaps may be included. Different other types of prostheses are most of the times considered. Grafts–Tissue scratch pieces may perhaps be detached involving the different or the same flaps or still tissue of body partially attached risen to a body but for restructuring or rearranging of the site of query of the body. Even though in surgery of cosmetics grafting is used time and again. It well may be gotten from single site sick persons of the body to place it within the body of another. The example issurgery of bypass. It is the surgery where a vessel of blood that is closed and implant bypasses tubes from other body parts. On the other hand, grafts may well be from other animals, persons or cadavers. Stoma construction, opening of a permanent or a half body stable opening The surgery of transfer, the organ contributor (fetched out from the body of the giver) is transferred into the body of the receiver and reassigned to the receiver in all essential ways (ducts, vessels of blood). Arthrodesis– it is a bones adjoining surgical relationship so that the bones can be able to grow collectively into lone.Fusion Spinalis an example of vertebrae adjoiningjoined which allows joining with a single part to grow. Digestive regionmodificationinsurgerybariatric forweight reduction of ahernia refurbishment,prolapsed or fistula Various other treatments include: clearance of blood, ducts clogged or different vessels subtraction of (stones) calculi removal of fluids accumulated damaged, diseased or tissue (dead) by debridement- removal Sex change operations Sometimes surgery is conducted to conjoined twins split Blood or expanders of blood are linked administratively to blood reimburse loss all through the process of surgery. When the action course is completestaples or suturesare used to cease openings. Once the cut is clogged, the agents of anesthetic are reversed and closed, and the patients are discharged for extubation and aeration (if it was administered anesthesia commonly). In the United States, the enlightenment era that starts from the (1680 circa to 1800) is the age of life of the Westerns wars. In this era, the thinkers and writers reject precedent superstitions. Apart from that the writers and thinkers chose to put emphasis on the scientific, cultural life and the intellectual that rolls in the 18th century center. For this the main reason of the legitimacy and authority is the main source of ad vocation. The enlightenment philosophers have envisioned a scientific sense. As the U.S constitution reflects itself the encouragement and desire for the innovation of science and scientific creations. Thus, the U.S has the power and support of Congress that helps develop full art of science by safely securing for limited to inventors and writers the rights exclusive related to their discoveries and writings. This has influencedAmerica to have the most advanced technology on medicine (biology). The expenses of Healthcare in the United States have climbed up gradually. Majority of Americans have preferred to travel overseas for elective processes or have at least considered going overseas as a possibility. In relation to the Times New York book, regarding the citizen of U.S who journeyed Belgian to undergo a hip replacement due to the lack of U.S insurers to cover this claim, this has influenced hundreds of America’s citizens to consider the same path. Earle (1983) tells that, â€Å"In 2007, Shopenn’s Michael surgery cost amount of U.S dollars closes to $100,000. Actually the cost came around to be $ 13,700 including all the fares, fees, medicine and hospital cost. This hospital was in Belgium, Tourhout.’’ Governments abroad regulate fees of medicine, despite the fact that majority of hospital and offices of doctors are managed privately. Some few days past living days, Americans are most agreeable more than willing to travel abroad since they ap preciate the quality found there, whereas several years ago they did not have that opinion. This is supported by the medical tourist association, which is the industry in the United States that facilitates and supports such travel (Hardin and Roberta 34). The increasing amount of American medical tourists and the United States citizens tend to be individuals who don’t have insurance or people whose insurance doesn’t adequately cover the process they need. Their target time and again depends on their literary ties. For instance, Spanish speaking patients and citizens might support Latin America. Ten years ago, many Americans who travelled overseas for less prices concern went to nations like Thailand, Mexico and over the boundary to India. A number of patients are now to Europe travelling, where better care at great hospitals often costs a portion of what is paid in the United States. This is made easy by the private facilitators. The private facilitators help in making arrangements, pairing doctors with patients and hospitals and organizing travel plans (Schumpelick 21). In the most recent years, hospitals and their respective governments in Europe have joined the field and are currently promoting their services. This idea is applied so as to make it simpler for citizens and patients from abroad- whether from Russia, Africa, North America or Middle East to view Europe as a solution due to its reasonable prices and high quality. Thompson 2012 says that â€Å"The East Coast people head from the coast of east to Europe, whereas the coast of west people travels to Asia like Thailand and Korea. There numbers are growing and they go there for the treatment as the U.S healthcare costs are exorbitant. The main factor to drive this is common background and quality.† A consortium of health care providers and hospitals in Europe is considering setting up a plan to magnetize and care for foreign patients. Surgery costs are about one fifth as much in Europe as in the United States. The doctors and the patients agree on a price and must sign an agreement be fore surgery according to the law. Hospitals and clinics in Europe offer an evident advantage for Americans (Thompson 21). Several programs are in line to minimize the cost of surgeries in the United States. This should be considered by the victims who are willing to travel to Europe for surgery process. With a massive increase in demand for mutual replacements as baby boomers period, holding down costs is significant to hospitals as well as patients. But before the readers start booking tickets to overseas, they ought to know that numerous programs are in line to lower the price of joint substitution surgery in the United States. With a huge boost in demand for joint substitution as baby boomers age, holding along costs is vital to hospitals as well as patients. A study by Norton, in the article of basic science and clinical evidence that was published in 2008 found that the programs were two-pronged success: a number of patients if not all choose hospitals that meet their prices. More significant, many hospitals decide to reduce their prices so that patients would be more than likely to choose them. Th e program in the United States includes services like BidMedi that allows lower cost medical care online for patients shopping, whether same or in different country. Surgery is a technology comprising of a physical involvement on muscles and tissues. As a common rule, a procedure is well thought-out as surgical when it involves closing of a formerly continued wound or cutting of patient’s tissues. Whether the surgery that one requires is an urgent medical process such as a gastric bypass or a hip replacement; cosmetic surgery like rhino-plastic or breast implants, there is always a definite advantage and benefit to looking towards surgery overseas. Surgery abroad is made easy by the private facilitators. Works Cited Aston, Sherrell J, Douglas S. Steinbrech, and Jennifer L. Walden.Aesthetic Plastic Surgery. Philadelphia: Saunders Elsevier, 2009. Print. Bhatia, Shivani.The Surgery Book: For Kids. Bloomington: AuthorHouse, 2010. Print. Earle, A S.Surgery in America: From the Colonial Era to the 20th Century. New York u.a: Praeger, 1983. Print. Hardin, Sonya R, and Roberta Kaplow.Cardiac Surgery Essentials for Critical Care Nursing. Sudbury, Mass: Jones and Bartlett Publishers, 2010. Print. Jarrell, Bruce E.Nms Surgery Casebook. Philadelphia: Lippincott Williams Wilkins, 2003. Print. Norton, Jeffrey A.Surgery: Basic Science and Clinical Evidence. New York, NY: Springer, 2008. Print. Klingensmith, Mary E.The Washington Manual of Surgery. Philadelphia, Pa: Lippincott Williams Wilkins, 2007. Print. Schumpelick, Volker.Atlas of General Surgery. Stuttgart: Thieme, 2009. Print. Sullivan, Deborah A.Cosmetic Surgery: The Cutting Edge of Commercial Medicine in America. New Brunswick [u.a.: Rutgers University Press, 2001. Print. Thompson, Lana.Plastic Surgery. Santa Barbara, Calif: Greenwood, 2001. Print.